list of medications that cause dry eyes

In: GCY Chiou, ed. Miserocchi E, Baltatzis S, Roque MR, et al. Approximately 20% of previously successful contact lens wearers may need to decrease their wearing time, use preservative-free lubricating eye drops or discontinue contact lens wear while on this medication.18. 2nd ed. Boston: Butterworth Heinemann, 2001. Michigan: Taylor and Francis, 1999:225-83. Identify the ocular side effects of systemic medications. Dry eyes can be caused by reduced tear production or increased evaporation from the eye's surface, but doctors rarely mention dry eyes as a drug side effect. Recent case reports suggest that herbal medicines may also be responsible for severe dry eyes (Oh et al, Clinical and Molecular Hepatology, Sep. 2013). Schaumberg DA, Buring JE, Sullivan DA, et al. Popular medicines like Zoloft (sertraline) and Paxil (paroxetine) belong to a different class of antidepressants, called selective serotonin reuptake inhibitors (SSRIs). A surprising number of drugs have what is referred to as anticholinergic activity. If a medication contributed to your symptoms, we would like to learn about that as well. D ry eye is a multi-factoral disease of the tears and ocular surface; one such factor is the patient’s use of systemic medications.1 Many common systemic medications can affect ocular tissues, and medications that contribute to dry eye symptoms are present in many categories of commonly prescribed and over-the-counter (OTC) medications. 2. But if someone is suffering from drug-induced dry eyes (or dry mouth), it is absolutely essential that this information be communicated to a physician to see if an alternative medication might not be appropriate that would not cause this adverse reaction. This can lead to dry eyes in rheumatoid arthritis, lupus and Sjogren’s syndrome. Xiidra. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. Clinically important ocular reactions to systemic drug therapy. That is why diabetes, herpes eye infection and laser eye surgery (LASIK) may sometimes result in dry eyes. Tests and procedures that may be used to determine the cause of your dry eyes include: 1. Dry eye complaints will disappear after medication use is discontinued, although it may take several months for the complaints to wane. Encephale. Optom Mgmt. Measuring the volume of your tears. 8. Ophthalmic toxicity by systemic drugs. 1. Tears can be inadequate for many reasons. The newer, more site-specific (H1 selective) antihistamines like Zyrtec (cetirizine, McNeil Consumer), Clarinex (desloratadine, Merck) and Allegra (fexofenadine, Sanofi-Adventis) are less likely to cause ocular dryness, but they may affect the tear film. Physicians and pharmacists rarely mention dry eyes as a drug side effect. Fraunfelder FT, Fraunfelder FW. 1. That may be because it doesn’t seem like such a big deal, especially compared to serious side effects like liver or kidney damage, heart attack or stroke. Certain classes of drugs are known to cause eye problems. As eye care providers, we can be valuable in detecting ocular side effects of systemic medications, advising our patients and communicating with other members of our patients’ healthcare teams. Some of these medications are essential for good health. These are available as eye drops [Trusopt® (dorzolamide), Azopt® (brinzolamide)] as well as pills [Diamox (acetazolamide) and Neptazane® (methazolamide)]. Dry eyes is a common condition that occurs when your tears aren't able to provide adequate lubrication for your eyes. In general, these effects occur with OTC preparations—most commonly with Benadryl (diphenhydramine, McNeil Consumer) and Chlor-Trimeton (chlorpheniramine, Schering)—and in recent offerings, such as Claritin (loratadine, Schering). Widely prescribed anti-anxiety medications and tricyclic antidepressants can produce dry eye side effects. A review article in the Journal of Ophthalmology (online, Aug. 27, 2012) lists many such drugs and discusses this topic in detail. Ocular side effects of selected systemic drugs. They point out that the more medications a person is taking, the greater the likelihood that a combination could contribute to dry eyes. Antipsychotic Drugs, Antidepressants and Parkinson’s Medications Can Cause Dry Eye. Jaanus SD, Bartlett JD, Hiett, JA. People are surprised to learn that even non-prescription medications could be contributing to their uncomfortable eyes. Common Medication Examples. In this test, blotting strips of paper are placed under … 3. Xiidra® (lifitegrast ophthalmic solution 5%) became FDA … List of drugs associated with a side effect named as Blurred Vision and related drug information. Dry eye is often a side effect of certain medications. Copyright © 2021 Jobson Medical Information LLC unless otherwise noted. Medications that can cause this include Adipex (for obesity), Celebrex (inflammation), Lamictal (seizures), Mevacor (elevated cholesterol), Tylenol (pain ­relief) and Zantac (ulcers). There are various ways that medications contribute to dry eye syndrome. These are available as supplements and in foods such as flaxseed, salmon and sardines. 2000;35(2):92-6. 18. Brand name examples include Zoloft, Paxil, Elavil, Endep and Sinequan. There are many potential causes for seeing double or for vision that suddenly blurs. J Drugs Dermatol. Debra A. Schaumberg, Sc.D., O.D., M.P.H., and colleagues reported a 69% increase in dry eye symptoms in women who were taking estrogen compared to the control group.10 Additionally, the study reported that women who were taking a progesterone or progesterone combination also experienced a 29% increase in dry eye symptoms over women not on HRT. Antihistamines and Decongestants High Blood Pressure. Imagine sandpaper under your eyelids. Xiidra (Shire), like … 20. Bartlett JD. Even though Roche Pharmaceuticals pulled Accutane from the market in 2009, generic versions of the drug may still be available by prescription. He is also a diplomate in the Primary Care Section of the American Academy of Optometry. Ocular effects of systemic drugs. In general, these medications affect and reduce tear production (or more specifically, production of water that constitutes the aqueous layer) from the lacrimal glands, resulting in dryness of the eyes. Except for brinzolamide, all CAI s are … The effect of these medications, however, is not as profound as earlier generation antihistamines. Antihistamines. … 2001 Nov;286(17):2114-9. Dermatologic Medications If you have ever gotten a foreign object in your eye you know how distressing that can feel until you get it out. A major drug in this class is Cytoxan (cyclophosphamide, Bristol-Myers Squibb), which is also used to treat ocular cicatricial pemphigoid and primary Sjögren syndrome. 2008 Jan;145(1):60-73. This incredibly unpleasant condition can be caused by a number of things. www.optometric.com/article.aspx?article=70708, Delay of Final Contact Lens Rule Requested by Congress, Conventional, Accelerated CXL Both Effective in Children, Diagnostic Tool Aids Refractive Assessment, Ray Tracing Offers Customizable LASIK Approach, Making the Diagnosis with the TFOS DEWS II. Ibuprofen, a common OTC pain medication, can cause dry eye in addition to blurred vision, refractive changes, diplopia and color vision changes, especially when the higher dosages (up to 800mg) are prescribed.13 Darvocet-N (propoxyphene napsylate and acetometaphin, USP) reportedly decreases tear secretion.14 Lortab (hydrocodone and acetaminophen, USP) combinations can also produce a dry eye. Drug-Induced Ocular Side Effects. 1992;2(4):73-96. Ocul Surf. 19. Antidepressants, Psychosis, and … Antihistamines are combined with anticholinergics in many OTC medications, such as cold preparations, sedatives, antidiarrheals and nasal decongestants.8 These combination medications induce dry eye, along with the commonly known effects of anticholinergics, which include mydriasis and decreased papillary response to bright light.8, Hormones A review article in the Journal of Ophthalmology (online, Aug. 27, 2012) lists many such drugs … Santaella RM, Fraunfelder FW. Reproduction in whole or in part without permission is prohibited. All rights reserved. But just ask someone with dry eyes how it affects their quality of life, and you will quickly learn that this is not a minor complication. Am J Ophthalmol. Bowling is in private group practice in Tuscaloosa, Ala. As always, the best course is to educate our patients about the role their medications play in their dry eye complaints. Share your own story about dry eyes below. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options. H2 receptor antagonists, like all antihistamines, can cause dry eye symptoms. Dry eye in post-menopausal women using hormone replacement therapy. Optom Mgmt. 12. Hormone replacement therapy and dry eye syndrome. Discuss the benefits and risks with your doctor. Decreased meibomian gland function also impacts the production of the lipid layer of the precorneal tear film, leading to tear film instability and enhanced surface evaporation, which results in dry eye syndrome. … 2002 Jan;109(1):111-8. Proton pump inhibitors have caused dry eye complaints, although this information does not appear in their individual package inserts. 2007 Apr;5(2):75-92. These include diuretics (water pills), antihistamines, antidepressants, drugs that lower cholesterol, beta-blockers and birth control pills. Physicians prescribe systemic beta blockers to treat angina pectoris, essential hypertension, myocardial infarctions and migraine headaches.4 Beta blockers reduce lysozyme levels and immunoglobulin A, causing a decrease in aqueous production and subsequently leading to symptoms of dry eye.5 Patients using beta blockers also exhibit corneal anesthesia, decreased tear film break-up times and ocular irritation. www.optometric.com/article.aspx?article=70708 (Accessed April 2011). 1993 Sep;9(3):196-211. Gastrointestinal Medications Dry Eye Culprits of the Drug World. 13. “Many doctors think erectile dysfunction drugs cause … This report, based on observations on 25,000 post-menopausal women, showed evidence of a significant increased risk of dry eye syndrome and severity of dry eye symptoms in women taking estrogen. 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Graedon is a pharmacologist who has dedicated his career to making drug information to. Medication use is discontinued, although it may seem like a minor annoyance to who! Both drugs decrease aqueous secretion, and symptoms are transient and dose dependent.20 noted. Their dry eye symptoms dedicated his career to making drug information understandable to consumers available at www.optometric.com/article.aspx.

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