View abstract. Therapeutic Research Faculty 2020. Cinatl J, Morgenstern B, Bauer G, et al. Gatica-Ortega ME, Pastor-Nieto MA. Oh, G. S., Pae, H. O., Choi, B. M., Lee, H. S., Kim, I. K., Yun, Y. G., Kim, J. D., and Chung, H. T. Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. Tamir S, Eizenberg M, Somjen D, et al. N Engl J Med 1991;325:1223-7. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). View abstract. Licorice reduces body fat mass in obese men and women. Licorice can decrease potassium levels. View abstract. Liu J. View abstract. The combination of licorice and white peony can help to decrease the excess testosterone that is being produced by the ovaries in PCOS. Nutrition 2002;18(3):268-273. Life Sci 9-27-2002;71(19):2267-2277. Kitagawa, I., Chen, W. Z., Hori, K., Harada, E., Yasuda, N., Yoshikawa, M., and Ren, J. 2005 - 2023 WebMD LLC. View abstract. Licorice (Glycyrrhizae Radix) 15 g: NR: Zhao (2016) [36] . Pharmazie 2010;65(8):624-8. Taking too much licorice can cause high blood pressure. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. View abstract. 2018;38(2):617-8. View abstract. Amato P, Christophe S, Mellon PL. Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. Ir J Med Sci 2016;185(4):945-7. Liu C, Wang J, Yang J. View abstract. Liapina LA, Ammosova IaM, Novikov VS, et al. A. View abstract. Wong, A. L. and Chan, T. Y. Interaction between warfarin and the herbal product quilinggao. Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Immunology 1997;90(1):115-120. View abstract. Akbari N, Asadimehr N, Kiani Z. Preterm birth and licorice consumption during pregnancy. Saw palmetto. J Pharmacobiodyn 1984;7:304-11. View abstract. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Complement Ther Med. J Am Acad Dermatol 2011;65(4):699-714. This can be severe. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707. Licorice might decrease the effects of warfarin. View abstract. N Engl J Med 1999;341:1158. Dehours E, Vall B, Roug-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Am J Respir.Cell Mol.Biol. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Licorice has anti-acid and relieves the tension of gastrointestinal smooth muscle. Lin, J. C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. (Tokyo) 2008;54(3):244-249. View abstract. View abstract. View abstract. 2010 Nov;35(10):1587-93. Neurology 2010;75(21):1939-1941. The efficacy and safety of the combination of total glucosides of peony and leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. Goultschin, J., Palmon, S., Shapira, L., Brayer, L., and Gedalia, I. View abstract. View abstract. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. View abstract. Wang W, Tian DD, Zheng B, et al. For women taking oral contraceptives, there is a very small chance that this can counteract the effects of this medication. 17. Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. 2020;383(13):1263-1275. J Contemp.Dent Pract. 1991;78(1-2):1-6. But the potential side effects are real enough. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats. [13] A study in Japan compared the use of a . Nat Prod Res 2007;21(14):1234-1241. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. This week, The New England Journal of Medicine reported that a man with a poor diet died of cardiac arrest after eating a bag-and-a-half of black licorice daily for weeks. Some of these health benefits have also . Efficacy and tolerability of hydroalcoholic extract of Paeonia officinalis in children with intractable epilepsy: An open-label pilot study. View abstract. Drugs & Vitamins . Ha Y, Wang T, Li J, et al. Johns, C. Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. Licorice consumption and serum testosterone in healthy man. View abstract. Int Immunopharmacol 2012;14(1):27-31. Phytother Res 2008;22(2):141-148. Kumada T, et al. Taking licorice with paclitaxel might decrease the effects of paclitaxel. Am J Chin Med 2001;29(3-4):459-467. Licorice might decrease how quickly the body breaks down methotrexate. View abstract. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. View abstract. Ann Clin Biochem 2007;44(Pt 4):397-399. Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? Armanini D, Lewicka S, Pratesi C, et al. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Psychoneuroendocrinology. [A plant extract and its modified preparation in functional dyspepsia. J Am Soc Nephrol 2002;13(1):191-196. Murck H, Lehr L, Hahn J, Braunisch MC, Jezova D, Zavorotnyy M. Adjunct Therapy With Glycyrrhiza Glabra Rapidly Improves Outcome in Depression-A Pilot Study to Support 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Inhibition as a New Target. MacKenzie, M. A., Hoefnagels, W. H., Jansen, R. W., Benraad, T. J., and Kloppenborg, P. W. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. It's not suggested to take St. John's wort if you take blood thinners. View abstract. View abstract. Liu X, Li X, Li X, et al. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Some medications are moved in and out of cells by pumps. View abstract. View abstract. J Endocrinol Invest 1996;19:624-9. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Farese RV Jr, Biglieri EG, Shackleton CH, et al. Part 2: Effect of glycyrrhizic acid on the course of illness]. Serra, A., Uehlinger, D. E., Ferrari, P., Dick, B., Frey, B. M., Frey, F. J., and Vogt, B. Glycyrrhetinic Acid decreases plasma potassium concentrations in patients with anuria. View abstract. Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. Because of its beneficial effects, the licorice root has been dubbed the "Medicinal plant of 2012." Now scientists have discovered that licorice root from the papilionaceae or leguminous family . 2 in the perioperative stage of laparoscopic cholecystectomy]. View abstract. Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial. 2010;33(2):321-324. View abstract. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Migraine is a type of headache. BMJ 1997;314:731-2. Li C, Wang ZB. View abstract. Taking licorice along with "water pills" might make potassium levels drop too low. J Nat Prod 1980;43(2):259-269. View abstract. This could change the effects and side effects of these medications. View abstract. Wu, T. H., Chiu, T. Y., Tsai, J. S., Chen, C. Y., Chen, L. C., and Yang, L. L. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. Antiviral Res 2003;59(1):41-47. 2019;33(1):117-29. Phytother Res 2008;22:563-5. 2019;35:329-41. View abstract. View abstract. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers or health and adiposity. View abstract. View abstract. Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. How Much Is Too Much? Clin Pharmacol Ther 1996;59:62-71. Licorice, tobacco chewing, and hypertension. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. Hinoshita F, Ogura Y, Suzuki Y, et al. Practitioner 1973;210:820-3. Eisenburg, J. Chewing tobacco flavored with Licorice may cause serious side effects such as high blood pressure. View abstract. View abstract. Fuhrman, B., Volkova, N., Kaplan, M., Presser, D., Attias, J., Hayek, T., and Aviram, M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Phytother Res. The sweet stuff in your kids' trick-or-treat buckets may come with a bitter side effect. Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. View abstract. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. View abstract. Harada M, Suzuki M, Ozaki Y. . 1987;(10):46-48. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Intern Med 2007;46:575-8. An Med Interna 1995;12(1):33-35. View abstract. View abstract. Eur J Dermatol. 1. View abstract. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. Planta Med 1991;57(2):119-121. View abstract. However, when Angelica Sinensis was tested in combination with products containing other substances, its activity was reduced. View abstract. View abstract. Braz J Infect Dis 2016;20(6):534-8. Pak J Med Sci 2022;38(1):271-275. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. View abstract. View abstract. Licorice might increase how quickly midazolam is broken down by the body.